The so-called birthplace of American wine means resilient vines from Thomas Jefferson's time and historic buildings paired with new wine-making techniques (monticellowinetrail.org). To convene with the past, stay at the Clifton Inn, the circa-1799 former home of First Daughter Martha Jefferson (doubles from $205; cliftoninn.net).
The hacienda-style wineries near this northern Baja town 70 miles south of San Diego date to the late 19th century, when missionaries planted sun-loving native and European varietals, such as nebbiolo (ensenada.com). For a breezy stay, try the oceanfront Casa Natalie Resort and Spa (doubles from $252; casanatalie.com).
Front Range, CO
The dramatic peaks and mile-high air provide an unforgettable setting for floral viogniers and Bordeaux-style reds (coloradowine.org). Unwind at The Broadmoor, the sprawling 90-year-old grand dame of Rocky Mountains indulgence (doubles from $265; broadmoor.com).
Just an hour's drive from Austin, the slopes of Texas Hill Country are filled with the scents of lavender and peaches. Sip locally grown French reds and forti- fied Texas sherry (texaswinetrail.com), then retire to trellised Rose Hill Manor (doubles from $155; rose-hill.com).
Napa Valley, CA
The resort towns of the picturesque Napa Valley are as abundant with shops, spas and gourmet eateries as they are with world-class wineries producing fruity New World varietals, such as cabernet sauvignon (napavalley.com). Our hotel pick is The Carneros Inn, luxe and impeccably manicured (doubles from $355; thecarnerosinn.com).
This Canadian cobblestoned lakeside village is an oenophile's dream, with 18 wineries reachable by foot or bicycle (niagaraonthelake.com). After hours, dine in style (talented chefs abound), then soak in the luxury of the Oban Inn & Spa (doubles from $150; obaninn.ca).
Okanagan Valley, BC
This slice of green between the Cascades and the Monashees in Canada is a study in contrasts, offering cool breezes and desert sun, an ideal setting for 60-plus wineries (bcwine.ca). Anchor yourselves at Walnut Beach Resort on Lake Osoyoos, and watch the sun set as you sip a local vintage (doubles from $139; walnutbeachosoyoos.com).
Seneca Lake, NY
The wineries dotting the cool blue perimeter of this upstate lake have made a name producing grapefruitlike rieslings and complex ice wines (senecalakewine.com). In between tastings, go fishing or gaze at waterfalls, then relax in the sparkling new Harbor Hotel in Watkins Glen (doubles from $159; watkinsglenharborhotel.com).
Willamette Valley, OR
The pinot noirs from this valley just outside Portland are some of the world's best; snatch up bottles from the excellent low-yield wineries before they sell out (willamettewines.com). Book at the nine-room Brookside Inn to share 22 green acres with only a handful of other guests (doubles from $185; brooksideinn-oregon.com).
Yakima Valley, WA
Hot days and cool nights in this sun-soaked valley produce velvety cabernets and well-rounded merlots (wineyakimavalley.org). Once you've imbibed, retreat into a woodsy cottage at Whistlin' Jack Lodge (doubles from $200; whistlinjacklodge.com).