I think the OP was wanting a room for under $100 per night.......I could be wrong...but I doubt you will find that on the strip.
IMO-If you could possibly swing the money for $100 plus per night...I really enjoyed staying on the strip. I thought it was worth it. You don't have to deal with transportation so much to have a good time.
I do believe (someone can correct me if I am wrong) but the bus Deuce only goes on the strip...so if you stay off of it....you have to relay on taxi or rent a car which would also suck since parking is difficult. Depending on how long you stay and how much coming and going you plan to do...it might be worth staying on the strip and walking...opposed to off the strip and taxi.